新型四环素类抗生素——amadacycline

Amadacycline,a new tetracycline antibiotics

Amadacycline是新型抗菌氨基甲基四环素类药物,属于米诺环素的衍生物,具有广谱抗菌活性,抗菌谱与替加环素相似。体内外抗菌实验显示,amadacycline相对于其它抗生素,具有较强的广谱抗菌活性。前期临床实验显示:对复杂性皮肤和皮肤结构感染与利奈唑胺显示相似的疗效。另外,研究发现amadacycline与氨比西林、头孢噻肟、环丙沙星、克林霉素、庆大霉素、利福平、万古霉素没有药物间相互作用。Amadacycline具有良好的临床应用前景。

Amadacycline is a novel aminomethylcycline antibiotic with a broad spectrum of antibacterial activity, which is the similar as tigecycline. In clinical studies, amadacycline showed comparable efficacy to linezolid, and was no interaction between amadacycline and other antibiotics, including ampicillin, cefotaxime, ciprofloxacin, clindamycin, gentamicin, rifampicin, and vancomycin. Amadacycline has good clinical application prospect.