沼蛙皮肤分泌物镇痛及抗炎活性研究

Research on analgesic and anti-inflammatory activity of Hylarana.guentheri skin secretions

目的研究沼蛙皮肤表面分泌物的镇痛及抗炎药理作用。方法以健康小白鼠为试验动物,采用冰醋酸扭体法及甩尾法确认其镇痛效能;采用二甲苯小鼠耳壳炎症的方法研究其抗炎作用。结果沼蛙皮肤分泌物对冰醋酸小鼠扭体反应及小鼠甩尾实验有一定的镇痛作用,并且能有效的抑制二甲苯引起的炎症反应。结论沼蛙皮肤分泌物具有一定的镇痛及抗炎活性,对其活性的深入研究,将有助于开发出新的镇痛抗炎药物。

Purpose To reveal the analgesic and anti-inflammatory pharmacological effects of the Hylarana.guentheri skin secretions.MethodsHealthy mice were adopted as experimental animals,using acetic acid writhing and tail flick methods to confirm the analgesic efficacy.Auricular inflammation in mice using xylene method is used to confirm its anti-inflammatory effect.ResultsHylarana.guentheri skin secretions can inhibit the acetic acid writhing response in mice and in mice tail-flick test,and significantly inhibited xylene-induced inflammation.ConclusionHylarana.guentheri skin secretions have some analgesic and anti-inflammatory activity,and their activity in-depth study will help to develop a new analgesic anti-inflammatory drugs.