水凝胶载体应用于药物控释的数学建模进展

Progress on Mathematical Modeling of Controlled Drug Release Using Hydrogels as Drug Carrier

聚合物水凝胶是由亲水性聚合物链通过物理作用或化学键作用形成的三维网络结构,在受到环境变化刺激时会产生响应性,因而作为药物控释载体广泛应用于医药领域。文中介绍了可控释药系统的类型及其主要影响因素,综述了可控释药数学模型的发展与应用,比较性分析了经验/半经验模型与机理模型,并展望了未来的发展方向。

Polymeric hydrogels are three-dimensional polymer networks in which individual hydrophilic polymer chains are connected,either by physical association or by chemical bonds.Once stimulated by environmental changes,such as the variation of pH or temperature,hydrogels will respond intelligently and achieve a new equilibrium state in a short time,so they have a wide application in pharmaceutical domain as ideal carriers for drug controlled release.This paper introduced different types of controlled release systems and their major influencing factors,reviewed the development and application of mathematical models describing the drug release processes,comparatively analyzed empirical/semi-empirical models and mechanism models,and presented development trends.