摘要
目的初步探讨自拟消郁安神汤的抗抑郁作用。方法采用小鼠悬尾实验及强迫游泳实验观察消郁安神汤的抗抑郁作用。结果在小鼠强迫游泳实验和小鼠悬尾实验中,消郁安神汤能明显缩短两种"行为绝望"模型小鼠的不动时间,高剂量抗抑郁的效果最明显。结论消郁安神汤对"行为绝望"动物模型有抗抑郁作用。
OBJECTIVE To discuss the anti-depression effects of Xiaoyu Anshen decoction.METHODS Effects of Xiaoyu Anshen decoction was evaluated through mice forced swimming test and mice tail suspension test.RESULTS Xiaoyu Anshen decoction decreased the accumulative immobility time significantly in mice forced swimming test and mice tail suspension test,with high dose decoction being the best.CONCLUSION Xiaoyu Anshen decoction can improve the depressive condition of mice and have obvious effect of antidepression.
出处
《华西药学杂志》
CAS
CSCD
北大核心
2012年第2期125-127,共3页
West China Journal of Pharmaceutical Sciences
关键词
抗抑郁
消郁安神汤
悬尾试验
强迫游泳
敞箱实验
Anti-depression
Xiaoyu Anshen decoction
Tail suspending test
Forced swimming test
Open-field test