施氏鲟幼鱼肝性脑病组织病理学与细胞病理学研究

Histopathological and cytopathologocal study on hepatic encepha lopathy of amur sturgeon Acipenser schrenckii larvae

通过对患病和健康施氏鲟 (AcipenserschrenckiiBrandt)进行的比较解剖、组织病理学与细胞病理学、流行病学研究结果表明 ,患病施氏鲟无明显的外部症状 ,临床解剖所见肝脏病变严重 :肝淤血、坏死、糜烂。肝组织脂肪变性、水样变性明显 ,肝细胞核浓缩或淡染、变形、核仁裂解 ,内质网扩张 ,线粒体嵴融解、崩解 ,胞浆内大量脂滴和液泡并将细胞器排挤成团。脑组织水样变性致液化性坏死 ,脑细胞胞浆呈液化泡状 ,核变形、浓缩 ,细胞膜融解。肾组织发生局灶性病变 ,病变肾细胞胞浆内有脂滴和液泡 ,核变形、融解 ,线粒体嵴融解、崩解。其它器官、组织、细胞未见病变。研究认为肝组织为原发性、中毒性坏死 ,脑组织病变与肝组织病变有依赖性 ,脑坏死为继发性液化性坏死 ,肾脏病变亦为继发性局灶性病变。因脑坏死而致鲟鱼死亡。文中还探讨了致病原因和机理以及危害性。

Through comparative anatomic, histopathologic, cytopathologic and epideminologic studies on the ill (14 Ind.) and normal(1 Ind.)farmed amour sturgeon, Acipenser schrenckii. No pathogenic microorganism was found. Outer symptom of earlier ill amour sturgeon was not obvious. Through anatomy hepatic tissue degeneration was severely found. hepatic tissue was lipoid degeneration, watery degeneration and focal necrosis. Hepatic function changed from unusual to deterioration. The illness of encephalic liquefaction necrosis depend on the illness of hepatic tissue, encephalic cell was watery degeneration and necrosis, other organs tissues and cells was not found to be degeneration. Hepatic tissue degeneration was first, toxicopathy. encephalic liquefaction necrosis was secondary disease. The toxin that caused hepatic tissue degeneration came from the food. The cause of the illness and mechanism were also studied.