输卵管切除术对控制性超促排卵卵巢反应性的影响

Effect of salpingectomy on ovarian response to superovulation

目的探讨在体外受精-胚胎移植(IVF-ET)中输卵管切除术对卵巢反应性的影响。方法将222周期因输卵管因素行IVF-ET的患者分为A、B、C三组:A组为双侧输卵管阻塞组(100周期),B组为单侧输卵管切除组(43周期),C组为双侧输卵管切除组(79周期)。比较三组患者在IVF-ET周期中卵巢对控制性超促排卵(COH)的反应性及妊娠结局的差异。结果三组的各项观察指标比较,均无统计学差异。但对于双侧输卵管切除时间<6个月患者的人绒毛膜促性腺激素(hCG)注射日直径≥14 mm卵泡数(4.06±2.34)高于双侧阻塞组(3.50±2.02),有显著性差异(P<0.05)。结论在IVFET中,输卵管切除术及切除时间尚不会对卵巢的反应性及妊娠结局形成不良影响。

Objective： To investigate the effect of salpingectomy on ovarian response during in vitro fertilization-embryo transfer （IVF-ET） program. Methods：A retrospective study was performed in 222 infertility women treated by IVF-ET due to defect of fallopian tubes. The patients were divided into three groups： group A （100 cycles, patients with obstruction of fallopian tube）, group B （43 cycles, patients with previous unilateral salpingectomy）, group C （79 cycles, patients with previous bilateral salpingectomy）. The ovarian responses to superovulation and the outcomes of IVF-ET were evaluated. Results：There were no significant differences in various indicators （P〉0.05）. Comparing the patients who had undergone bilateral salpingectomy within 6 months with the patients suffered obstruction of fallopian tube, ovarian follicles more than 14 mm were significantly higher on the day of injection of hCG. Conclusions： Salpingectomy has no adverse effect on ovarian response to superovulation and the outcome of IVF-ET.