TOLL样受体抗体对鼠疟疾病理进程的影响

Effect of Anti-TLRs Antibodies on Pathological Course of Malaria in Rice

利用TOLL样受体抗体(TLRs)尾静脉注射并封闭对应TLR的方法,观察疟疾病理进程的变化。结果表明,TLR2、9、11抗体处理后小鼠的存活率在第10天分别为70%、0、0,对照组为50%;TLR2、9、11抗体处理后小鼠的红细胞感染率峰值分别为55%、61%、58%,对照组为52%。抗体封闭TLR2后,可提高小鼠的存活率;抗体封闭TLR9、11后,小鼠红细胞感染率显著升高而存活率显著降低。证明TLR是一类有潜力的抗疟药物或治疗辅助药物的靶点。

The toll-like receptors（TLRs） in rice were blocked by tail vein injection with corresponding anti-TLR antibodies and then GIMSA staining was used to observe the pathological course of malaria.The results showed that after treated with TLR2,9 and 11 antibody,the surviving rates of mice at day 10 were 70%,0 and 0,respectively and the peak of parasitemia were 55%,61%,58%,respectively,which were 50% and 52% in control group,respectively.It was indicated that by treating with TLR2 antibody,the surviving rate of infected mice could be increased.After treated with TLR9 and 11 antibodies,the parasitemia and mortality were significantly increased.It was proved that TLRs were potential targets of new anti-malarial drugs.