中药马蹄香和5种治疗胃肠病药物中的低聚糖含量测定和分析

Determination and Analysis of Oligosaccharides in Valeriana Jatamansii Jones and 5 Drugs for Gastrointestinal Diseases

目的深入认识马蹄香和5种治疗胃肠病药物中的低聚糖成分.方法应用戴安CS-3000离子色谱分析仪测定马蹄香散剂、蒙脱石散、盐酸小檗碱片、复方谷氨酰胺肠溶胶囊、参苓健脾胃颗粒和L-谷氨酰胺呱仑酸钠颗粒6种治疗胃肠病药物中的10种低聚糖含量.结果复方谷氨酰胺肠溶胶囊、马蹄香散剂和参苓健脾胃颗粒中含10种低聚糖量高.L-谷氨酰胺呱仑酸钠颗粒中没有检测出低聚糖.在单个的低聚糖含量中,半乳糖三糖的量在参苓健脾胃颗粒最高,其次为蒙脱石散和马蹄香散剂,毛蕊花糖的量在马蹄香散剂中最高,麦芽四至七糖的量在复方谷氨酰胺肠溶胶囊中较高.结论马蹄香散剂、蒙脱石散、复方谷氨酰胺肠溶胶囊和参苓健脾胃颗粒中低聚糖含量高,毛蕊花糖在马蹄香散剂中含量最高.

Objective To investigate the effective agents in the Valeriana Jatamansii Jones and 5 drugs for treatment of viral enteritis.Methods The content of 10 oligosaccharides in 6 drugs including Valeriana Jatamansii Jones,Dictahedral Smectite Powder,Berberine Hydrochloride Tablets,Compound Glutamin Entersoluble capsule,Shenling Jianpiwei Keli,L-Glutamine and Sodium Gualenate Granules for gastroenteral diseases was determined by DIONEX CS-3000 high performance liquid chromatography-iron analyzer in the study.Results The results showed 10 oligosaccharides were rich in the Compound Glutamin Entersoluble capsule,Valeriana Jatamansii Jones and Shenling Jianpiwei Keli.There was no oligosaccharides in the L-Glutamine and Sodium Gualenate Granules.There was higher content of the galactose in the Shenling Jianpiwei Keli,the Montmorillonite powder and Valeriana Jatamansii Jones,especially the galactose was rich in the Shenling Jianpiwei Keli.The verbascoses were rich in the Valeriana Jatamansii Jones.There were higher content of maltotetraose Dp4 and 7 in the Compound Glutamin Entersoluble capsule.Conclusions The oligosaccharides are rich in the Valeriana Jatamansii Jones,Compound Glutamin Entersoluble capsule,Shenling Jianpiwei Keli and montmorillonite powder.The verbascoses especially are rich in the Valeriana Jatamansii Jones.The higher content of the oligosaccharides in these drugs may be associated with improving intestinal micrflora and functions.