2型糖尿病FOXC2基因C-1702T多态性与血清总胆固醇相关性

The Preliminary Analysis of the FOXC2 C-1702T Polymorphism is Associated with Cholesterol

目的探讨叉头框C2(FOXC2)基因3’非翻译区C-1702T多态性与2型糖尿病的相关性.方法选择云南省汉族人280例,其中2型糖尿病患者159例,无糖尿病家族史的健康对照121例.应用半巢式PCR检测FOXC2基因3’非翻译区C-1702T多态性.结果在2型糖尿病组和对照组中,FOXC2基因C-1702T的基因型和等位基因频率无统计学意义(P>0.05),并与性别无关(P>0.05).在2型糖尿病患者中与FOXC2基因1702杂合子和突变型(C/T和T/T)相比,FOXC2基因1702C/C野生型者,其血清胆固醇的水平明显升高(P<0.05).结论 FOXC2基因C-1702T基因多态性与性别及2型糖尿病没有相关性.2型糖尿病患者FOXC2基因3’非翻译区C-1702T多态性与血清总胆固醇相关.

Objective To investigate the association between the forkhead transcription factor C2（FOXC2）C-1702T transition in the putative promoter region and type 2 diabetes.Methods 280 han people in Yunnan province were selected as subjects.A case-control study was performed in 159 type 2 diabetic patients and 121 control subjects.The FOXC2 gene C-1702T polymorphism was detected by heminested PCR.Results FOXC2 C-1702T allele and genotype distribution did not differ between patients with type 2 diabetes and control subjects（P0.05）,and had no association with gender.The C/C genotype was associated with higher level of cholesterol（P0.05）among type 2 diabetic patients.Conclusions FOXC2 C-1702T is not associated with gender and type 2 diabetes.FOXC2 C-1702T is associated with serum cholesterol.