高频彩色超声检测2型糖尿病患者血管内皮功能的临床价值分析

Clinical Research of Vascular Endothelium Function in Type 2 Diabetes Patients with High-Frequency Color Ultrasonography

目的评估高频彩色超声检测2型糖尿病(T2DM)患者血管内皮功能的临床价值.方法测定77例T2DM患者和36例正常人的一般情况和生化指标,采用高频彩色多普勒超声测定2组的右侧肱动脉血流介导的血管扩张率(FMD)及含服硝酸甘油片后的内皮非依赖性舒张功能(NID).结果 2组间在年龄、总胆固醇、低密度脂蛋白方面无统计学差异,糖尿病组的体重指数、空腹血糖、甘油三酯明显高于对照组,但高密度脂蛋白明显低于对照组(P<0.05).糖尿病组的FMD明显低于对照组(P<0.01),含服硝酸甘油后的NID与对照组比较,差异无统计学意义(P>0.05).结论高频彩色超声对2型糖尿病患者血管内皮功能的诊断和评估有较高临床实用价值.

Objective To explore the clinical value of high-frequency color ultrasonography in evaluating the vascular endothelium function in type 2 diabetes patients.Methods The general conditions and biochemical indexes of 77 type 2 diabetes patients and 36 normal control subjects were measured.Right brachial artery flow was detected for the flow mediated dilation（FMD）and endothelium independent dilation（EID）after taking nitroglycerin in the two groups with high-frequency color ultrasonography.Results The age,total cholesterol and low density lipoprotein had no significant difference between two groups,but body mass index,fasting blood-glucose and triglyceride in T2DM group were significantly higher than those in control group whereas high density lipoprotein was significantly low in T2DM group.In T2DM group,FMD was significantly decreased compared with that in normal control group（P0.01],but NID after taking nitroglycerin orally had no significant difference between two groups（P0.05）.Conclusion High-frequency color ultrasonography has a high clinical diagnositic value in evaluating vascular endothelium function in type 2 diabetes patients.