诱导型细胞的研究进展

Recent Progress in Induced Cells

胚胎干细胞(ES细胞)和诱导型多能干细胞(iPS细胞)的研究进展为生物学基础研究注入了新的活力,然而免疫排斥、致瘤性以及诱导效率低等缺陷制约其进一步快速发展和临床应用.最近,科学家借鉴iPS细胞诱导技术和传统的诱导体系,将终末分化细胞直接诱导为功能性细胞,如心肌细胞、神经细胞和肝脏细胞,称为诱导型细胞.这些研究进展极大地促进了细胞分化、重编程和表观遗传学的研究,也为人类再生医学的研究提供了新的途径.

The achievements of embryonic stem（ES） cells and induced pluripotent stem（iPS） cells provide new routes for biological research.However,the problems of immunological rejection,teratoma formation and low efficiency limit the further application.Recently,taking advantage of the systems for iPS cell derivation and traditional induction technologies,scientists induced terminally differentiated cells into functional cells such as cardiomyocytes,neurons and hepatocyte-like cells.These inspiring progresses boost the research on cell differentiation,reprogramming and epigenetics,providing new direction for regenerative medicine studies.