人类基因组信息量的扩增速率受重组的影响

The Growing Rate of The Information Quantity of The Human Genome is Modulated by Recombination

减数分裂重组是基因组进化的重要驱动力,揭示基因组在与重组有关进化压力下的进化规律是基因组进化研究领域的重要课题.一系列证据表明基因组编码信息量在进化过程中随时间增加.重组率与自然选择效率成正比,因此,在进化过程中基因组信息量的增加速率可能会受到重组率的影响.本文定义表征编码信息量增加速率的信息参数,以人类基因组为研究对象,分析基因组信息量的增加速率与重组率的关系,发现二者显著正相关,表明重组可能是加快基因组信息量增长的重要途径.

Meiotic recombination is driver of genome evolution.It is important to explore the rule of genome evolution under the control of evolutionary pressure linked to recombination.The coding information quantity of a genome（CIQ） always grows during evolution.Recombination rate is proportional to selection efficiency,thus the growing rate of coding information quantity of a genome（GRCIQ） might be mediated by recombination rate.In this study,a parameter is defined to characterize GRCIQ,and the correlation between GRCIQ and recombination rate is analyzed in the human genome.The results show that there is a positive correlation between them,indicating recombination is likely to be an important pathway to increase GRCIQ.