和胃止呕方联合盐酸昂丹司琼对实体瘤化疗患儿呕吐的疗效观察

Treatment of Vomiting in Children Patients with Solid Tumor by Hewei Zhiou Recipe Combined Ondansetron Hydrochloride

目的观察和胃止呕方联合盐酸昂丹司琼对实体瘤患儿化疗呕吐的疗效。方法将80例2007年1月—2010年1月北京儿童医院肿瘤门诊及住院有明显呕吐症状的实体瘤化疗患儿按照随机数字表分为治疗组和对照组,每组40例。对照组给予盐酸昂丹司琼4mg静脉滴注,治疗组在对照组疗法基础上在化疗期间加用和胃止呕方。采集第1～6个疗程结束时两组患儿呕吐症状、程度分级数据并进行组间比较。结果第1疗程结束时,两组患儿呕吐反应程度比较,差异无统计学意义(Z=-0.470,P>0.05);治疗组第2～6疗程结束时呕吐反应程度减轻,与对照组比较,差异均有统计学意义(Z值分别为-2.966、-3.256、-3.453、-4.870、-3.627,P<0.01)。结论和胃止呕方联合盐酸昂丹司琼能有效缓解实体瘤患儿化疗时出现的呕吐症状。

Objective To observe the therapeutic efficacy of Hewei Zhiou Recipe（HZR） combined ondansetron hydrochloride（OH） in treating vomiting in children patients with solid tumor.Methods Eighty children patients with solid tumor at the Department of Tumor,Beijing Children＇s Hospital from January 2007 to January 2010 were randomly assigned to the treatment group and the control group by the random digit table method,40 in each group.OH 4 mg was intravenously dripped to patients in the control group.Those in the treatment group took HZR on the basis of the same treatment as for the control group.The vomiting score and degree of the two groups were collected and compared by the end of the 1st to the 6th therapeutic course.Results There was no statistical difference in the vomiting degree between the two groups by the end of the 1st therapeutic course（Z=-0.470,P0.05）.The vomiting degree was lessened in the treatment group by the end of the 2nd to the 6th therapeutic course,showing statistical difference when compared with the control group（Z=-2.966,-3.256,-3.453,-4.870,-3.627,respectively,P0.01）.Conclusion HZR combined OH could effectively relieve the vomiting of children patients with solid tumor during chemotherapy.