女性年龄对因输卵管因素行IVF-ET治疗患者妊娠结局的影响

The age affected on pregnancy outcomes of tubal factor infertility women undergoing in vitro fertilization-embryo transfer

目的探讨女性年龄对因输卵管因素导致不孕患者行体外受精-胚胎移植(IVF-ET)治疗的妇女妊娠结局的影响。方法回顾性分析在青岛市妇女儿童医院生殖中心行IVF-ET治疗的468个周期,按女性年龄大小分为4组,比较不同年龄组之间的Gn用量、获卵数、胚胎着床率和临床妊娠率、流产率。结果本研究平均妊娠率为30.34%。≤30岁组、31～34岁组、35～49岁组、≥40岁组的胚胎着床率分别为21.4%、19.7%、14.0%、8.7%,各组差异有显著(P=0.04);临床妊娠率分别为38.7%、28.0%、26.9%、17.1%,各组差异有显著性(P=0.03);流产率分别为8.6%、19.6%、25.0%、50.0%,差异有显著性(P=0.03)。结论患者年龄是影响IVF-ET妊娠结局的重要因素。随年龄增加,尤其是35岁以上的妇女,胚胎着床率与临床妊娠率明显降低,流产率显著升高。

Objective To study the age affected on pregnancy outcomes of tubal factor infertility women undergoing in vitro fertilization-embryo transfer（IVF-ET）.Methods A retrospective analysis on Qingdao Women and Children Hospital for IVF-ET treatment of 468 cycles was carried on,which were divided into four groups according to females’ age,number of eggs,implantation rates,pregnancy rates and abortion rates between the different age groups were compared.Results In this study the average pregnancy rate was 30.34%.The implantation rate of the four groups（≤30 age group,31-34 age group,35-49 age group and ≥40 age group） were 21.4%,19.7%,14.0% and 8.7%,respectively.There was significant difference among the four groups（P=0.04）;Clinical pregnancy rate respectively for 38.7%,28.0%,26.9% and 17.1%,also has significantly difference（P=0.03）;Abortion rate respectively for 8.6%,19.6%,25.0% and 50.0%（P=0.03）.Conclusion Age is an important factor affecting IVF-ET pregnancy outcome in patients.As age increasing,especially over 35 years old,pregnancy rate and implantation rate significantly decreased and abortion rates increased significantly.