左旋甲状腺素对良性甲状腺结节的疗效及相关因素分析

Efficacy of Levothyroxine for the Treatment of Benign Thyroid Nodule and Its Correlative Factors

【目的】评价左旋甲状腺素（L-T4）抑制性治疗对良性甲状腺结节的疗效及影响疗效的相关因素。【方法】选取良性甲状腺结节患者154例，随机分为L-T4治疗组和空白对照组，接受L-T4治疗或随访观察。随访12个月后，对两组的结节直径变化情况和相关的参数进行评价。【结果】L-T4治疗组甲状腺结节最大横截面直径缩小（-2．95±2．76）mm；而对照组结节最大横截面直径增大（2．02±2．84）mm，（P=0．001）。相关性分析显示：治疗组中，结节直径的变化与起始的结节直径及年龄呈负相关。【结论】L-T4是治疗良性甲状腺结节一种有效的治疗手段，能够有效的抑制良性甲状腺结节的生长。其疗效与起始结节直径及患者年龄相关。

[Objective] To evaluate the efficacy of levothyroxine（L-T4 ） suppressive therapy for benign thyroid nodule and its correlative factors. [Methods] A total of 154 patients with benign thyroid nodule were chosen. All patients were randomly divided into L-T4 treatment group and control group. After 12 months of follow up, the change of the nodule diameter and the correlative parameters in 2 groups were evaluated. [Results] The diameter of maximal nodule cross section in L-T4 treatment group decreased（2. 95±2. 76mm）, while that in control group increased（2. 025±2.84, P =0. 001）. The correlative analysis showed that the nodule diameter in treatment group had negative correlation with original nodule diameter and patients age. [Conclusion] L-T4 suppressive therapy is an effective therapy. It can efficiently inhibit the growth of benign thyroid nodule. The efficacy is related to the original nodule diameter and patients age.