地佐辛治疗急性心肌梗死胸痛疗效观察

Observation on the Efficacy of Dezocine for the Treatment of Chest Pain after Acute Myocardial Infarction

【目的】观察地佐辛（Dezocine）治疗急性心肌梗死所引起的胸痛的临床疗效及安全性。【方法】选择急性心肌梗死持续胸痛患者50例，在常规治疗的基础上，随机分为地佐辛与吗啡组各25例，分别采用地佐辛或吗啡给予镇痛治疗。采用疼痛模拟评分（VAS）评定镇痛效果，统计不良反应发生情况。【结果】地佐辛与吗啡组VAs评分在各时点无统计学差异（P〉0．05），不良反应发生率地佐辛组明显低于吗啡组，两组间比较有统计学差异（P〈0．05）。【结论】地佐辛治疗急性心肌梗死引起的持续胸痛效果明显且副作用较少，安全性较好。

[Objective] To observe the clinical effectiveness and safety of dezocine for the treatment of chest pain caused by acute myocardial infarction. [Methods] Fifty patients with continuous chest pain after a- cute myocardial infarction were chosen and randomly divided into dezocine group（ n = 25） and morphine group （ n = 25） based on the routine therapy. Both groups were given dezocine or morphine for analgesia, respective- ly. [Results] There was no significant difference in VAS score at each time point between dezocine group and morphine group（ P〉0.05）. The incidence of adverse reaction in dezocine group was obviously lower than that in morphine group, and there was significant difference between 2 groups（ P〈0.05）. [Conclusion] Dezocine for the treatment of chest pain caused by acute myocardial infarction has obvious efficacy, less adverse reaction and good safety.