住院精神分裂症患者并发无症状高尿酸血症的影响因素

Prevalence of asymptomatic hyperuricemia and its influencing factors in schizophrenic inpatients

目的了解住院精神分裂症患者无症状高尿酸血症(Hyperuricemia,HUA)的患病率及其相关因素。方法对上海市普陀区精神卫生中心住院的精神分裂症患者作调查,测定其代谢指标,采用2004年中华医学会风湿病学分会的原发性痛风诊治指南(草案)标准定义无症状高尿酸血症。共入组259例,其中男153例,女106例,平均年龄(52±9)岁。结果住院精神分裂症患者高尿酸血症的患病率为13.9%(36/259),女性的患病率(15/106,14.2%)与男性的患病率(21/153,13.7%)无统计学差异(χ2=0.009,P>0.05)。患病率随年龄增加而增加。Logistic回归发现高尿酸血症与精神分裂症总病程、代谢综合征、LDL-C、TC与精神分裂症患者伴发HUA正相关,为其危险因素;HDL-C与精神分裂症患者伴发HUA负相关,为其保护因素。结论精神分裂症患者较多存在无症状高尿酸血症,疾病早期即应予以关注。

Objective To investigate the prevalence of asymptomatic hyperuricemia （ASHUA） in schizophrenic inpatients and its influencing factors. Methods 259 schizophrenic inpatients [ 153 males, 106 females; mean age （52 ± 9） years] treated in Shanghai Putuo Mental Health Center were involved in the study. Metabolic indexes were measured and the ASHUA was diagnosed according with the definition of Primary Gout Treatment Guidelines （draft） established by Chinese Rheumatology Association （2004）. Results The prevalence of ASHUA was 13.9% （36/259） in schizophrenic inpatients. There was no significant difference in prevalence between male （21/153,13.7%） and female （ 15/106, 14.2% ） schizophrenic patients （X： = 0. 009, P 〉 0.05 ）. The prevalence of ASHUA increased with the age. Logistic regression analysis found that total duration of schizophrenia, metabolic syndrome, LDL-C, TC were risk factors of ASHUA. Blood level of HDL-C was protective factors of ASHUA （P 〈 0.05 ）. Conclusion Asymptomatic hyperuricemia occurres in many schizophrenic inpatients. Much attention should be paid even in the early stage of illness.