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卤代吸入麻醉药对发育期大脑学习记忆功能及中枢神经递质受体系统的影响

Effects of Halogenated Inhalation Anesthetics on Learning and Memory Function and Central Neurotransmitter Systems in Developing Brain
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摘要 新型卤代吸入麻醉药(如七氟烷、异氟烷等)因具有麻醉效能高、可控性强、呼吸道刺激小等特点,在小儿临床麻醉中具有显著优势。婴幼儿神经系统具有较高的可塑性,因此吸入麻醉药可能更易造成未成熟大脑神经元退行性改变,甚至延迟的持续性学习记忆功能损害。目前关于吸入麻醉药影响发育期大脑认知功能的具体机制尚未定论。 New halogenated inhalation anesthetics such as sevoflurane and isoflurane have significant advantages in pediatric clinical anesthesia due to their features of high-performance,good controllability,and less respiratory tract irritation.Infant nervous system has high plasticity,so alogenated inhalation anesthetics could cause degenerative changes in the immature brain neurons,even the continuous delay in learning and memory impairment.So far,the mechanisms of volatile anesthetics affecting the cognitive function of developing brain is not conclusive.
作者 唐冬梅 徐桂萍
机构地区 石河子大学医学院 新疆维吾尔自治区人民医院麻醉科
出处 《医学综述》 2012年第7期976-978,共3页 Medical Recapitulate
基金 国家自然科学基金(81160016) 新疆维吾尔自治区自然科学基金(2011211A056)
关键词 卤代吸入麻醉药 学习记忆 中枢神经递质受体 Halogenated inhalation nesthetics Learning and memory Central neurotransmitter receptors
分类号 R614 [医药卫生—麻醉学]
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参考文献29

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医学综述
2012年 第7期

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