摘要
子宫内膜异位症(EMs)的发病机制和治疗一直是困扰妇科医师的难题。由于伦理学问题,不能直接在人体上进行实验研究,更不能反复地进行有创性检查监测疾病的进展,限制了EMs的研究。裸鼠模型是EMs理想的动物模型,能够准确地再现疾病的特点,并能反映疾病的发展变化,尤其在研究血管形成等因素在EMs中的作用和抗血管生成治疗的应用方面更具有价值。
Pathogenesis and treatment of endometriosis are always puzzle for gynaecologists.In addition,ethical considerations limit the performance of experiments.It is hardly possible to give experimental evidence in humans,and it is not possible to monitor the disease progression with repeated traumatic examination.The nude mouse models are appropriate animal models for the study of endometriosis.They can exactly reproduce the characteristic and reflect the development of endometriosis.They are especially of high value for the evaluation of blood vessel development and the efficacy of angiogenesis inhibitors.
出处
《医学综述》
2012年第7期979-982,共4页
Medical Recapitulate
基金
天津市应用基础研究计划面上项目(06YFJMJC08800)
