原癌基因对肠黏膜屏障保护作用的研究进展

Research Progress of the Protective Effect of Proto-oncogene on Intestinal Mucosal Barrier

多种病理状态下肠黏膜屏障会受到损害,继而发生肠道细菌和内毒素移位,引发肠道外多脏器感染,严重时会导致全身炎性反应综合征,导致患者死亡。随着对原癌基因研究的深入,发现原癌基因除了可以引起细胞癌变外,也可参与细胞增殖,促进创伤组织的修复。了解肠黏膜屏障损害及修复机制对并发肠黏膜损害疾病的治疗和预防都有重要的临床意义。

In many pathologic conditions,intestinal mucosal barrier can be damaged,which will translocate intestinal bacterial and endotoxin to other organs,and lead to severe infection to multiple organs besides intestines,under serious condition may even lead to systemic inflammatory response syndrome and death.With the in-depth study of proto-oncogene,it′s found that proto-oncogene not only can cause cancer,but also can be involved in cell proliferation and promote the repair of wound tissue.Understanding the damage and repair mechanism of intestinal mucosal barrier has great clinical significance to the treatment and prevention of diseases with the complication of intestinal mucosal damage.