预防和降低丙烯酰胺毒性的几种抗氧化剂

Effect of antioxidants on preventing and reducing the toxicity of acrylamide

丙烯酰胺(AA)是一种对人体具有潜在致癌性的化合物,可导致细胞遗传物质DNA的损伤。高剂量的暴露会影响人和动物的神经系统与生殖系统,并对啮齿类动物具有一定的致癌性。一些生物抗氧化剂可以预防和降低AA对机体造成的危害,本文主要阐述了一些生物抗氧化剂对AA的抑制作用,尤其是生物抗氧化剂对于AA所致细胞毒性的保护作用。

Acrylamide was a toxic compound that could lead the damage of DNA in cetls.High doses of exposure of acrylamide could affect the nervous system and reproductive system of human and animals. It even had carcinogenicity to rodents.Some antioxidants played a significant role in preventing and reducing the toxicity of acrylamide,and this paper made a comprehensive overview about these antioxidants, especially the natural antioxidants on the protection effect of acrylamide-induced cell damage.