乙肝免疫球蛋白阻断乙肝病毒母婴传播效果研究

Hepatitis b immunoglobulin for blocking the hepatitis b virus mother-to-child transmission

目的:分析乙肝免疫球蛋白对于阻断乙肝病毒母婴传播的效果。方法:病例选自我科室门诊2010年1月～2011年3月接受孕期检查的HBV携带的132例孕妇,大三阳和小三阳的孕妇于孕24周开始接受HBIG注射治疗,携带者孕妇于孕28周开始接受HBIG注射。结果:孕24周与分娩前的乙肝标志物与HBV-DNA检查结果无显著差异(P>0.05)。HBIG阻断HBV母婴传播疗效,总有效率为75.71%。而HBIG阻断HBV疗效大三阳孕妇较携带者和小三阳孕妇疗效不佳,存在明显差异。新生儿接受疫苗接种和HBIG注射后12个月,HBsAb(+)率为86.43%,与新生儿出生时HBsAb(+)率75.71%相比,有较大改善。结论:对HBV感染的孕妇在孕24周后注射HBIG,阻断乙肝病毒母婴传播效果明显,新生儿出生后采用HBIG和HBV疫苗联合阻断HBV母婴传播临床效果显著。

Objective： To analyze the effects of hepatitis b immunoglobulin for blocking the hepatitis b virus mother-to-child transmission.Methods：A total of 132 cases pregnant women that confirmed as HBV carrier that visited our hospital during January 2010 and March 2011 were enrolled in this study,those shown HBsAg,HBeAg and Anti-HBc positive or HBsAg,Anti-HBe and Anti-HBc positive started to get HBIG injection from the 24th week of pregnancy,while HBV carriers started on the 28th week of preganancy.Results：Efficiency of HBIG blocking HBV mother-to-child transmission was 75.71%.But the efficiency of HBIG for blocking HBsAg,HBeAg and Anti-HBc positive or HBsAg,Anti-HBe and Anti-HBc positive pregnant women was different.For new born infants,after injection of HBIG,86.43% were shown as HBsAb（＋）,which is improved comparing with the 75.71% before injection.Conclusions： After injection of HBIG on the 24th week of pregnancy,effects of blocking the hepatitis b virus mother-to-child transmission in pregnant women with HBV infection is obvious,for new born infants,HBIG combing with HBV is effective on blocking HBV mother-to-child transmission.