子宫内膜异位症患者周期性瘀血的临床研究

Clinical study on periodic blood stasis of patients with endometriosis

目的:研究子宫内膜异位症的周期性瘀血变化及与子宫内膜异位症相关指标的关系,探讨子宫内膜异位症的发病机制。方法:80例子宫内膜异位症患者分为月经前组(分泌晚期)38例和月经后组(增生早期)42例。同期随机抽取因各种非子宫内膜异位症良性疾病行腹腔镜手术的病人为对照组。测定3组血瘀积分及分级、血液流变学变化、血清及腹腔液糖类抗原125(CA125)水平。结果:①月经前组、月经后组血瘀积分及分级、血液流变学的变化、血清及腹腔液中CA125表达明显高于对照组(P<0.01);两组比较,月经前组各指标均显著高于月经后组(P<0.05);②血液流变学变化、血清及腹腔液中CA125表达与血瘀积分呈正相关。结论:子宫内膜异位症患者周期性瘀血变化结合相关指标可较客观的反映子宫内膜异位症病变,为临床的辨证、治疗、以及进一步的研究提供依据。

Objective： To probe into the pathology of endometrosis,by studying the relationship between the periodic variation in blood stasis and endometrosis-related indexes.Methods： Choose 80 patients with endometrosis as subject to observe,and divide them into the premenstrual group（late secretion） consisting of 38 patients and the after menstruation group（early hyperplasia） consisting of 42 patients.Meanwhile,randomly select patients who have laparoscopic surgery for various benign non-endometriosis diseases as the control group.The three groups are tested for their value and classification of blood stasis,their change in hemorheology and their CA125 level in serum and celiac liquid.Results： 1.The two EMT groups are much higher than the control group in the value and classification of blood stasis,the change in hemorheology and the CA125 level in serum and celiac liquid,and the difference is significant（P0.01）;In the comparison of various indexes of the two EMT groups,the premenstrual group is higher than the after menstruation group,and the difference is significant（P0.05）.2.There is a positive correlation between the value of blood stasis,the change in hemorheology,and the CA125 level in serum and celiac liquid.Conclusion： The pathological change of endometrosis can be objectively reflected by combining the periodic variation in blood stasis of patients with endometrosis and other related indexes,and the result also lays foundation for clinical differentiation and treatment,as well as further researches.