肺平滑肌瘤病1例临床病理及组织起源分析

Pulmonary Leiomyomatosis： A Clinicopathological and Histological Original Study of One Case

目的分析肺平滑肌瘤病的临床、病理学特征及组织起源。方法通过光镜及免疫组化观察，并结合临床资料及相关文献复习，探讨肺平滑肌瘤病的临床病理学特征、鉴别诊断及组织起源。结果患者为中年女性患者，有子宫平滑肌瘤病史，双肺多发小结节样病变，经开胸肺活检，结合形态及免疫组化显示为平滑肌源性肿瘤，参考文献及l临床病理特点，最后诊断为肺平滑肌瘤病。结论肺平滑肌瘤病是～种少见的肺内良性肿瘤，患者多为中年女性，有子宫平滑肌瘤病史，组织起源不清，预后良好。

Objective To analyze the clinicopathologic characteristics histological origination of leiomyomatosis in the lung. Method To discuss pulmonary leiomyomatosis clinicopathologic features, differentia/diagnosis and histological origination by microscopy and immunohistochemical observation ,combing with clinical presentation and literature review. Results We report a middle-aged woman with a history of benign uterine leiomyoma present ten years ago and showed multiple nodules in the lung. Combining with the results of wedge biopsy, morphology and immunohistochemistology, it is smooth muscle source tumor. Based on the literature and clinicopathologic characters of it, the diagnosis is pulmonary leiomyomatosis. Conclusions Pulmonary leiomyomatosis is a rare condition that occurs predominantly in women with a history of uterine leiomyoma. The origin of the tumor is controversial, prognosis is not bad.