支气管哮喘与HLA-DPB_1基因相关性的研究

A Study on the Associations between HLA-DPB_1 Loci and Bronchial Asthma of Shenyang Hans' Individuals

目的:探讨辽宁沈阳地区汉族支气管哮喘患者的人类白细胞抗原(human leukocyte antigen,HLA)-DPB1的相关性。方法:采用序列特异性引物聚合酶链反应(polymerase chain reaction-sequence specific primer,PCR-SSP)技术检测辽宁沈阳地区汉族100例支气管哮喘患者及100例健康者HLA-DPB1*0201等位基因频率。结果:哮喘组HLA-DPB1*0201基因频率(4%)显著低于对照组(25%)(P<0.05)。结论:提示HLA-DPB1*0201基因可能为辽宁沈阳汉族支气管哮喘患者的保护性基因。

Objective：To investigation the association between Human leukocyte antigen DPB1（HLA-DPB1） gene polymorphism and bronchial asthma among the Hans in the Shenyang.Method：Sequence-specific primer polymerase chain reaction（PCR-SSP） was used to detect gene frequencies of HLA-DPB1＊0201 in 100 cases with bronchial asthma,100 health control people.Result：The gene frequency of HLA-DPB1 ＊ 0201 was 4% in the asthma population and 25% in the healthy population.There was the significant difference between them（P0.05）.Conclusion：The result showed that HLA-DPB1＊0201 was probably resistant gene in bronchial asthma among the Hans in the Shenyang.