急性冠状动脉综合征患者缺血修饰蛋白与同型半胱氨酸水平关系的研究

The research of relationship between serum ischemia modified album and homocysteine in patients with acute coronary syndrome

目的探讨缺血修饰蛋白(IMA)与急性冠状动脉综合征(ACS)患者同型半胱氨酸(Hcy)的关系。方法入选400例受试对象,分为对照组(n=144)、不稳定性心绞痛(UA)组(n=190)和急性心肌梗死(AMI)组(n=66)。抽血分离血清,采用白蛋白钴结合试验测定血清IMA,结果用ACB(清蛋白钴结合能力)值表示。采用化学发光法测定血清Hcy。比较各组ACB值和Hcy的血清浓度差异,分析二者之间的相互关系。结果 UA组(59.1±5.2)U/L和AMI组(52.5±3.1)U/L的ACB值明显低于对照组(65.0±5.7)U/L(P均<0.05)。UA组(17.2±5.2)μmol/L和AMI组(21.6±3.8)μmol/L的Hcy浓度明显高于对照组(12.4±2.0)μmol/L(P均<0.05)。UA组和AMI组的ACB值与Hcy浓度(r=-0.32和-0.68,P均<0.05)呈负相关。结论 IMA不仅有助于ACS的诊断,而且对于评估ACS患者的预后有一定的参考价值。

Objective To study the relationship between serum ischemia modified album（IMA） and homocysteine（Hcy） in patients with acute coronary syndrome（ACS）.Methods Serum IMA and Hcy levels were determined in were determined in 190 patients with unstable angina pectoris（UAP） and 66 patients with acute myocardial infarction（AMI） within 3 hours after onset of chestpain and 144 healthy people as controls.And the determination of Serum IMA was indicated with the value of ACB（album in cobalt binding）.Results The value of ACB was lower in unstable angina（UA） and acute myocardial infarction（AMI）groups than that in control group[control（65.0±5.7）,UA（59.1±5.2） VS AMI（52.5±3.1）U/L]（P〈0.05 respectively）.The Hcy level was increased in UA and AMI groups,compared with control group[control（12.4±2.0）,UA（17.2±5.2） VS AMI（21.6±3.8）μmol/L]（P〈0.05 respectively）.The value of ACB was negatively correlated with Hcy in UA and AMI groups（r=-0.32 and-0.68,P〈0.05 respectively）.Conclusions Not only is IMA one of the earliest sensitive indicators for clinical diagnosis of early myocardial ischemia in patients with ACS,but is useful for estimating the consequence of patients with ACS.