重度子痫前期产妇外周血和胎盘组织中脂质的研究

The study of lipid in peripheral blood serum and placenta with preeclampsia pregnancy

目的探讨脂质代谢在子痫前期发病中的作用。方法用酶法检测28例重度子痫前期产妇(子痫前期组)和30例健康孕足月产妇(对照组)的外周血甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-c)、高密度脂蛋白胆固醇(HDL-c)水平;用油红染色法检测10例子痫前期组和10例对照组胎盘组织中脂质水平。结果子痫前期组外周血中TG、TC、LDL-c水平明显高于对照组(P<0.05),HDL-c水平明显低于对照组(P<0.05)。子痫前期胎盘组织中的脂质水平明显高于对照组(P<0.05)。结论子痫前期产妇存在明显的高脂质代谢异常。异常脂质代谢在子痫前期发病中起着一定的诱导作用。

Objective： To discuss the effectiveness of lipid in the pathogenesis of preeclampsia.Methods： 28 cases of severe preeclampsia and 30 normal pregnant women were selected in this study.The peripheral blood serum were analyzed for the levels of triglyceride（TG）,total cholesterol（TC）,low density lipoprote cholesterol（LDL-c）,high density lipoprote cholesterol（HDL-c） by enzymid methods.The lipid levels of placentas with 10 cases of severe preeclampsia and 10 normal pregnant women were analyzed by oil red staining.Results： Compared with normal pregnant women,the levels of TG,TC,LDL-c were increased significantly,the levels of HDL-c was decreased in severe preeclampsiawomen（P〈0.05）.The lipid was generally deposited in placentas in severe preeclampsia women.Conclusion： The abnormal metabolism of hyperlipermia were found significantly in severe preeclampsia.The abnormal lipid metabolism possibly was a induction in the pathogenesis of preeclampsia.