急性皮质下脑梗死后血管性认知功能障碍的血管性危险因素研究

Risk factors for vascular cognitive impairment after acute cerebral infarction in sub-cortex

目的探讨急性皮质下脑梗死后血管性认知功能障碍的相关危险因素。方法根据VCI诊断标准将182例急性皮质下脑梗死患者分为:有VCI发生组(A组)81例,无VCI发生组(B组)101例。调查一般情况、疾病史、MMSE评分结果,并记录相关理化检查结果。结果 (1)A组与B组相比,在年龄、文化程度、高血压、糖尿病、高血脂、动脉粥样硬化方面差异有统计学意义。(2)MMSE评分与文化程度呈显著正相关。结论高龄、低文化水平、高血压、糖尿病、高脂血症、动脉粥样硬化与VCI的发生密切相关,其中糖尿病是急性皮质下脑梗死后VCI发生的危险因素。

Objective To evaluate the risk factors related to vascular cognitive impairment（VCI）after acute cerebral infarction in sub-cortex.Methods According to the diagnostic classification of VCI,182 patients suffering from acute cerebral infarction were selected,81 patients with VCI,while another 101 cases without VCI as control group.Questionnaires were included in common conditions,history of disease,MMSE score result and recording correlative physical-chemical examination results.Results（1）In the VCI group,age,educational level,hypertension,diabetes,hyperlipidemia and athero-sclerosis were significantly more than those in the other group,there were statistical differences.（2）Educational levels were significantly intimately related to the MMSE scores.Conclusion Advanced age,lower educational level,hypertension,diabetes,hyperlipidemia and atherosclerosis were intimately related to VCI.Diabetes was the independent risk factor for the VCI after acute cerebral infarction in sub-cortex.