豨桐滴丸和豨桐胶囊的溶出度对比研究

Comparison on dissolution between Xitong Dropping Pills and Xitong Capsule

目的对豨桐滴丸和胶囊进行溶出度的比较。方法采用HPLC法测定样品中奇壬醇,并以此为指标比较了豨桐滴丸和胶囊在水、0.1 mol/L HCl、0.5%十二烷基硫酸钠中的溶出度。结果在30 min时,豨桐滴丸在3种不同介质的溶出度达到81.24%、80.24%、88.72%,而豨桐胶囊只有71.35%、70.35%、76.95%。结论豨桐滴丸中奇壬醇的溶出明显优于豨桐胶囊。

Objective To compare the dissolution of Xitong Dropping Pills and Xitong Capsule.Methods Contents of kirenol in Xitong Dropping Pills and Xitong Capsule were determined by HPLC,and the dissolutions in three different dissolution media water,0.1 mol/L HCl,and 0.5% sodium dodecyl sulfate（SDS） were compared.Results The dissolutions of kirenol in Xitong Dropping Pills in three different dissolution media were 81.24%,80.24%,and 88.72% in 30 min,while the dissolutions of Xitong Capsule were 71.35%,70.35%,and 76.95%,respectively.Conclusion The dissolution of kirenol in Xitong Dropping Pills is higher than that in Xitong Capsule.