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Synthesis and Anti-tumor Activity of Novel Glycyrrhetinic Acid Derivatives

Synthesis and Anti-tumor Activity of Novel Glycyrrhetinic Acid Derivatives
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摘要 Twenty-five derivatives of glycyrrhetinic acid(GA) modified on the A-ring,at C30 and C11 positions were synthesized.Their in vitro cytotoxicity against various cancer cell lines[henrietta lacks strain of cancer cells(HeLa),human hepatocellular liver carcinoma cells(HepG2) and human gastric carcinoma cells(BGC-823)] was evaluated by standard MTT[3-(4,5-dimethyl-2-thiazol-yl)-2,5-diphenyl-2H-tetrazolium bromide] assay.All the tested derivatives were found to have stronger cell growth inhibitory than their parent compound GA.Among them,compounds 3a,5a,and 8d have similar activity on HeLa cell line,and compound 8a has similar activity on HeLa,HepG2 and BGC-823 cell lines as Gefitinib. Twenty-five derivatives of glycyrrhetinic acid(GA) modified on the A-ring,at C30 and C11 positions were synthesized.Their in vitro cytotoxicity against various cancer cell lines[henrietta lacks strain of cancer cells(HeLa),human hepatocellular liver carcinoma cells(HepG2) and human gastric carcinoma cells(BGC-823)] was evaluated by standard MTT[3-(4,5-dimethyl-2-thiazol-yl)-2,5-diphenyl-2H-tetrazolium bromide] assay.All the tested derivatives were found to have stronger cell growth inhibitory than their parent compound GA.Among them,compounds 3a,5a,and 8d have similar activity on HeLa cell line,and compound 8a has similar activity on HeLa,HepG2 and BGC-823 cell lines as Gefitinib.
出处 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2012年第2期214-219,共6页 高等学校化学研究(英文版)
基金 Supported by the Project-sponsored by Scientific Research Foundation for Returned Overseas Chinese Scholars,Ministry of Education of China(No.20080890) the Key Project of Chinese University Science Research of Liaoning Educational Commission,China(No.L2010433)
关键词 Glycyrrhetinic acid derivative Anti-tumor activity Structure modification Glycyrrhetinic acid derivative Anti-tumor activity Structure modification
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