T细胞亚群比例失调在血栓闭塞性脉管炎发病机制中的作用

Imbalance of T cell subpopulations in immunologic pathogenesis of throm boangiitis obliterans

关于血栓闭塞性脉管炎(TAO)的发病机制目前尚无定论。一些学者认为TAO的发生与机体免疫功能紊乱关系密切,主要表现在体液免疫功能亢进和细胞免疫功能低下,而T细胞在机体免疫反应的调控中可能起着主导作用。目前,有关TAO病人外周血T细胞亚群的研究,及其与抗动脉抗体(AAA)产生的关系,以及在疾病发生和发展中所起的作用,国内外报告甚少。

The T cell subpopulations of peripheral blood from 60 TAO patients and 40 normal subjects were detected with 3 kinds of monoclonal antibodies using indirect immunofluoresence technique. Meanwhile, the antiarterial antibodies (AAA) and circulating immune complex (CIC) from the sera of above patients and normal subjects were also determined. The results of the experiment suggests: (1) The functional disorders of immunoreguiating T cell (T4^+, T8^+),especially the severe decrease of T8^+ cell percentage play an important role in the pathogenesis of TAO;(2) The imbalance of T cell subpopulations have close relation to the production of antiarterial antibodies.