CA199在卵巢畸胎瘤诊断中的临床意义

The clinical significance of CA199 in ovarian teratoma

目的探讨血清CA199在卵巢畸胎瘤诊断中的临床意义。方法收集2005年6月至2010年6月在我院就诊的256例卵巢畸胎瘤手术患者为研究对象,且术前进行包括CA199在内的4项肿瘤标记物的检查。结果 4种肿瘤标记物中,CA199表达阳性率最高,且与畸胎瘤的大小、单双侧、所含成分等显著相关(P<0.05)。结论卵巢畸胎瘤的直径越大、未成熟成分多,为双侧时,其阳性率明显升高,推测CA199在卵巢畸胎瘤的诊断及鉴别诊断中具有一定的临床意义。血清CA199升高时,无论对侧卵巢外观是否正常,均应仔细检查对侧卵巢,同时剖探。CA199显著升高时,提示卵巢未成熟畸胎瘤的可能性较大。

Objective To evaluate the clinical significance of CA199 in ovarian teratoma.Methods We retrospectively studied 256 patients at our hospital between June 2005 and June 2010,whose tumor markers including CA199 was studied before the operation.Results Among the four tumor markers,CA199 showed the highest positive rate.The level of CA199 had obvious correlation factor with the diameter and bilateral or unilateral and composition of the teratoma（P0.05）.Conclusion CA199 may have significance in the diagnosis of ovarion teratoma.When CA199 hoisted,we must chect contralatral and split and explorate ovarian carefully wether the ovarian looks normol or not.CA199 hoisted may point out the tumor is the immature ovarian teratoma.