氟苯尼考颗粒与氟苯尼考粉在猪体内的药物动力学比较

Comparative Pharmacokinetics of Florfenicol Granule and Florfenicol Powder in Pigs

健康猪14头随机分为A、B2组,分别单剂量胃管灌服氟苯尼考粉和颗粒,按体质量给药剂量均为30 mg/kg,进行比较药动学研究.高效液相色谱法(HPLC)测定其血药浓度.采用药动学分析软件WinNonlin 5.2.1的非房室模型处理血药浓度-时间数据.氟苯尼考粉灌胃给药的主要药物动力学参数为:t1/2β=(10.22±0.18)h,ke=(0.07±0.01)h-1,tmax=(1.67±0.48)h,Cmax=(24.68±1.13)μg·mL-1,AUC=(190.97±16.60)μg·mL-1·h,MRT=(8.33±0.42)h,tcp=(17.66±1.52)h.氟苯尼考颗粒灌胃给药的主要药物动力学参数为:t1/2β=(16.36±4.14)h,ke=(0.05±0.01)h-1,tmax=(5.71±0.47)h,Cmax=(12.23±0.78)μg·mL-1,AUC=(155.44±6.59)μg·mL-1·h,MRT=(14.96±0.35)h,tcp=(23.03±0.49)h.试验结果表明,与氟苯尼考粉相比,氟苯尼考颗粒的消除半衰期更长,有效血药浓度维持时间也较长.

Fourteen healthy pigs were divided into two groups of 7 pigs each.The pigs in group A were orally administrated with single dose of florfenicol powder at 30 mg/kg.The pigs in group B were also orally administrated with single dose of florfenicol granule at 30 mg/kg.Comparative study on the pharmacokinetics of florfenicol powder and florfenicol granule was carried out.Plasma concentration of florfenicol was determined by HPLC.The concentration-time data of florfenicol were analyzed by non-compartmental model based on pharmacokinetic software WinNonlin 5.2.1.The main pharmacokinetic parameters of powder following oral administration were： t1/2β =（10.22±0.18） h,ke =（0.07±0.01） h-1,tmax =（1.67±0.48） h,Cmax=（24.68±1.13） μg·mL-1,AUC=（190.97±16.60） μg·mL-1·h,MRT=（8.33±0.42） h,tcp=（17.66±1.52） h.The main pharmacokinetic parameters of granule following oral administration were ： t1/2β =（16.36±4.14） h,ke=（0.05±0.01） h-1,tmax=（5.71±0.47） h,Cmax=（12.23±0.78） μg·mL-1,AUC=（155.44±6.59） mg·mL-1·h,MRT=（14.96±0.35） h,tcp=（23.03±0.49） h.The results showed the granule of florfenicol after oral administration had slower elimination and longer effective time of the blood medicine density maintenance.