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辛伐他汀对慢性阻塞性肺疾病大鼠MMP-1 MMP-9及抗基质金属蛋白酶-1表达的影响 被引量：2

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摘要 慢性阻塞性肺疾病（chronic obstructive pulmonary dis-ease,COPD）是一种以不完全可逆、呈进行性发展的气流受限为特征的疾病状态,气流受限与长期吸烟及其他有害颗粒或有害气体所致的肺部慢性炎症有关[1]。大量研究表明,他汀类药物可抑制肺部慢性炎症,从而降低COPD患者的发病率和病死率。本实验采用气道内滴注脂多糖（LPS）加被动吸烟法制备COPD大鼠模型[2],通过早期辛伐他汀干预,
作者 杨书艳 李卫东 田新瑞
机构地区 山西医科大学第二医院干部保健科
出处 《中国药物与临床》 CAS 2012年第4期450-451,共2页 Chinese Remedies & Clinics
关键词 慢性阻塞性肺疾病 PD大鼠模型 基质金属蛋白酶-1 辛伐他汀 MMP-1 MMP-9 PULMONARY 肺部慢性炎症
分类号 R563.9 [医药卫生—呼吸系统]
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参考文献11

二级参考文献65

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  • 2钟晓芃,朱宝玉.基质金属蛋白酶及组织型金属蛋白酶抑制物与慢性阻塞性肺疾病的关系[J].国外医学（呼吸系统分册）,2005,25(6):455-457. 被引量：8
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共引文献294

同被引文献38

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中国药物与临床
2012年 第4期

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