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DNA甲基化与肿瘤 被引量：6

DNA Methylation and Tumor
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摘要 DNA甲基化类型改变是人类肿瘤中最常见的基因变化之一 ,癌基因的低甲基化与抑癌基因的高甲基化在肿瘤发生、发展中的基因表达调控。 The alteration of DNA methylation types is one of the most common genetic changes in human tumor genome The hypermethylation of tumor suppression gene and hypomethylation of oncogene may play an important role in maintenance of the stability of gene structure and the regulation of gene expression during the generation and development of tumor
作者 孔祥东 王军 张思仲
机构地区 华西医科大学附一院医学遗传学教研室
出处 《浙江肿瘤》 CAS 2000年第2期119-121,共3页
关键词 甲基化 CpC岛 甲基转移酶 基因表达 肿瘤 methylation CpG island methyltransferase gene expression
分类号 R730.231 [医药卫生—肿瘤]
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参考文献8

  • 1Hsu DW,Lin MJ,Lee TL,et al.Two major forms of DNA(cytosine-5)methyltransferase in human somatic tissues[].Proceedings of the National Academy of Sciences of the United States of America.1999
  • 2Sullivan MJ,Taniguchi T,Jhee A,et al.Relaxation of IGF2 imprinting in Wilms tumours associated with specific changes in IGF2 methylation[].Oncegene.1999
  • 3Suske G.The Sp-family of transcription factors[].Gene.1999
  • 4Derrane M.Gene imprinting: making an impression on cancer research[].Journal of the National Cancer Institute.1999
  • 5Costello JF,Fruhwald MC,Smiraglia DJ,et al.Aberrant CpG-island methylation has non-random and tumour-type-specific patterns[].Nature Genetics.2000
  • 6Bird AP.The essentials of DNA methylation[].Cell.1992
  • 7Wolffe AP,Jones PL,Wade PA.DNA demethylation[].Proceedings of the National Academy of Sciences of the United States of America.1999
  • 8Lyon MF.Imprinting and X-chromosome inactivation[].Results and Problems in Cell Differentiation.1999

同被引文献65

  • 1刘建余,覃扬,孙芝琳,孙泽芳.人原发性肝癌中p16,p15基因CpG岛甲基化研究[J].四川大学学报（自然科学版）,2002,39(S1):127-132. 被引量：5
  • 2张翠娟,李晓明,刘宗石,周庚寅,李红,马超,孙研琳.肝细胞癌中RIZ1基因甲基化的研究[J].中华肝脏病杂志,2004,12(10):631-631. 被引量：3
  • 3姚群峰,康新江,郝巧玲,张利平,周宜开.5-氮杂脱氧胞苷对肿瘤细胞p16基因甲基化及表达的影响[J].环境与职业医学,2005,22(5):385-387. 被引量：4
  • 4Klein CB, Costa M. DNA methylation, heterochromatin and epigenetic carcinogens. Murat Res, 1997,386 : 163.
  • 5Leonard CT, Sachs DP. Enviromental tobacco smoke and lung cancer incidence. Curt Opin Pulm Med, !999,5 : 189-193.
  • 6Herman JG, Umar A, Polyak K, et al. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Nail Acad Sci USA, 1998,95:6870-6875.
  • 7Buermeyer AB, Suzanne M, Deschenes SM, et al. Mammalian DNA mismatch repair. Annu Rev Gene, 1999,33:533-564.
  • 8Wang YC, Lu YP, Tseng RC, et al. Inactivation of hMLH1 and hMSH2 by promoter methylation in primary non-small cell lung tumors and matched sputum samples. J Clin Invest, 2003,111:887-895.
  • 9Murata H, Khattar NH, Kang Y, et al. Genetic and epigenetic modification of mismatch repair genes hMSH2 and hMLH1 in sporadic breast cancer with microsatellite in stability. Oncogene, 2002,21 : 5696,5703.
  • 10Deng G, Chen A, Hong J, et al. Methylation of CpG in a small region of the hMLH1 promoter invariably correlates With the absence of gene expression. Cancer Res, 1999,59 : 2029- 2033.

引证文献6

二级引证文献16

浙江肿瘤
2000年 第2期

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