用氰丙烯酸酯粘合剂、结膜切除和表层角膜切除联合的方法治疗蚕蚀性角膜溃疡

Cyanoacrylate adhesive with conjunctival resection and superficial keratectomy in Mooren's ulcer

目的 评估应用结膜切除、角膜表层切除和氰丙烯酸酯组织粘合剂联合治疗蚕蚀性角膜溃疡的疗效。方法 13例 15只眼蚕蚀性角膜溃疡应用结膜切除、角膜表层切除、氰丙烯酸酯组织粘合剂及局部、全身皮质类固醇联合方法进行治疗。病变严重程度根据角膜损害的厚度及病变范围来判断。结果 12只眼 (80 % )以血管性角膜斑痕完全愈合。3只眼 (2 0 % )用此方法治疗失败。

Objective To evaluate the efficacy of cyanoacrylate adhesive with conjunctival resection and superficial keratectomy in Mooren's ulcer.Methods Fifteen eyes of thirteen patients with Mooren's ulcer were treated with a combination therapy of local and systemic steroids,conjunctival resection,superficial keratectomy and application of cyanoacrylate tissue adhesive.The degree of pathological changes were judged based on the extent of corneal thinnig and of ulceration.Results Tweleve eyes(80%) healed completely with formation of a vascularised scars,while three eyes(20%) failed to respond to treatment.Conclusion Our study suggests and early intervention of this combined therapy with cyanoacrylate tissue adhesive application for effective control of Mooren's ulceration.