老年性脑梗死急性期血浆中凝血酶敏感蛋白含量变化及其临床意义

Change of plasma thrombospondin content and its clinical significance in elderly patients with acute cerebral infarction

目的 老年性 (6 0～ 82岁 )脑梗死住院患者血浆中凝血酶敏感蛋白 (TS)水平与脑梗死形成、病情及病程关系。方法 采用流式细胞术检测 6 0例老年性脑梗死患者血浆TS水平。结果 老年性脑梗死组血浆中血小板膜TS水平显著高于对照组 (P <0 0 1) ;重病人组又略高于轻病人组 (P <0 0 5 ) ;病后 6h组高于患病大于 96h组 (P <0 0 5 )。结论 血小板膜TS改变参与了脑血栓形成过程 ;血浆TS水平的异常增高可随病情的加重而升高 ,随病程的延长而下降。提示血浆中TS增高可能为脑梗死早期诊断和治疗的指标之一。

Objective To study the change of plasma thrombospondin(TS)content and its cilinical significance in elderly patients with acute cerebral in-fathction.Methods The contents of TS in plasma were measured in 60 hospialized patients with acute cerebral infaction by using the flow cytometry.Results The contents of TS were increased significan in patients with cerebral infarction (P<0.01),the more serious the diseaae patient was,the higher the content of TS was (P<0.05).The contents of TS detected within 6 hours after attack were higher than those detected 96 hours after(P<0.05).Conclusions TS is involved in the mechanism of cerebral infarction,and its level increases is with increasing severity and the course of cerebral infarction,suggesting that the increase of TS may serve as a sensitive index for the early diagnosis of cerebral infarction.