期刊文献+

间充质干细胞移植的两种治疗作用机制

Mechanisms of mesenchymal stem cells transplantation in repair of tissue injury
下载PDF
导出
摘要 间充质干细胞是组织工程学和细胞治疗学中理想的种子细胞,可参与受损组织的修复。间充质干细胞除了可通过自身分化为受损组织的细胞直接参与修复外,还可通过旁分泌的形式,分泌一系列细胞因子,发挥抗炎抗凋亡、促新生血管生成、改善组织灌注等作用,促进受损组织的内源性修复,而且这种间接修复可能比直接修复更为重要。
作者 高广周 孙涛
出处 《军医进修学院学报》 CAS 2012年第5期549-552,共4页 Academic Journal of Pla Postgraduate Medical School
基金 全军"十一五"课题基金项目(06MA017) 首都医学发展科研基金项目(2009-3083)~~
  • 相关文献

参考文献26

  • 1Qian H,Yang H,Xu W. Bone marrow mesenchymal stem cells ameliorate rat acute renal failure by differentiation into renal tubular epithelial-like cells[J].International Journal of Molecular Medicine,2008,(03):325-332.
  • 2Yokoo T,Ohashi T,Shen JS. Human mesenchymal stem cells in rodent whole-embryo culture are reprogrammed to contribute to kidney tissues[J].Proceedings of the National Academy of Sciences(USA),2005,(09):3296-3300.
  • 3Jiang W,Ma A,Wang T. Homing and differentiation of mesenchymal stem cells delivered intravenously to ischemic myocardium in vivo:a time-series study[J].Pflugers Archive,2006,(01):43-52.doi:10.1007/s00424-006-0117-y.
  • 4Ortiz LA,Gambelli F,Mcbride C. Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects[J].Proceedings of the National Academy of Sciences(USA),2003,(14):8407-8411.
  • 5Gupta N,Su X,Popov B. Intrapulmonary delivery of bone marrow-derived mesenchymal stem cells improves survival and attenuates endotoxin-induced acute lung injury in mice[J].Journal of Immunology,2007,(03):1855-1863.
  • 6Schmidt A,Ladage D,Steingen C. Mesenchymal stem cells transmigrate over the endothelial barrier[J].European Journal of Cell Biology,2006,(11):1179-1188.doi:10.1016/j.ejcb.2006.05.015.
  • 7Gnecchi M,He H,Liang OD. Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells[J].Nature Medicine,2005,(04):367-368.doi:10.1038/nm0405-367.
  • 8T(o)gel F,Hu Z,Weiss K. Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms[J].American Journal of Physiology-Renal Physiology,2005,(01):F31-F42.
  • 9Humphreys BD,Bonventre JV. Mesenchymal stem cells in acute kidney injury[J].Annual Review of Medicine,2008.311-325.
  • 10Hofmann M,Wollert KC,Meyer GP. Monitoring of bone marrow cell homing into the infarcted human myocardium[J].Circulation,2005,(17):2198-2202.doi:10.1161/01.CIR.0000163546.27639.AA.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部