葛根及其配伍治疗重症肌无力探析

The Research on Treatment of Myasthenia Gravis with the Root of Kudzu Vine and Other Herbs

重症肌无力是一种较为常见的神经科疑难病之一,其发病机制错综复杂,西医临床治疗乏效。而"脾主肌肉"为中医临床从脾胃论治重症肌无力提供了理论基础,但脾胃功能的发挥却是通过诸多归脾胃经药物实现的。葛根主归脾胃经,具有解肌与升津的双重功效,是调理脾胃功能治疗重症肌无力的关键,但复方配伍理论决定了葛根治疗重症肌无力功效发挥受临床用量及其配伍环境的影响,且"脾主肌肉"、肌肉与线粒体的相关性,为葛根及其配伍组合对重症肌无力治疗以线粒体为核心展开研究提供了可能。

Myasthenia gravis is a kind of commonly seen difficult disease in neurology.The pathogenesis is sophisticated and can not be treated by western medicine effectively.Spleen governing muscles provide the theoretical base for treatment from spleen and stomach with TCM,and the function is performed by herbs meridian tropism of which are spleen and stomach.The root of kudzu vine enters the meridians of spleen and stomach,can relieve muscle and promote salivation and is the key point to regulate the function of spleen and stomach in order to treating myasthenia gravis.However,the therapeutic effect is influenced by the dosage and compatibility when treating myasthenia gravis with root of kudzu vine.In addition,spleen governing muscle and the correlation of muscle and mitochondrial make it possible that the treatment of myasthenia gravis with the root of kudzu vine and the compatibility centered on the research of mitochondrial.