尿激酶静脉溶栓治疗急性脑梗塞疗效Meta分析

Meta-Analysis of Thrombolytic Therapy of Intravenous Urokinase in Acute Cerebral Infarction

目的 :综合评价尿激酶静脉溶栓治疗急性脑梗塞的临床疗效。方法 :采用固定效应模型及随机效应模型对 7个尿激酶静脉溶栓治疗急性脑梗塞的临床试验进行Meta分析。结果 :尿激酶静脉溶栓治疗急性脑梗塞的合并有效率是对照组的 4.85倍 ,95 %可信限为 2 .73～ 8.6 2 ,尿激酶静脉溶栓治疗急性脑梗塞的合并有效率与对照组相比差异有显著性 (χ2 =5 4.30 ,P <0 .0 0 1)。结论

To evaluate the clinical efficacy of thrombolytic therapy of intravenous use of urokinase in acute cerebral infarction,meta analysis of 7 random clinical trials of intravenous urokinase thrombolytic therapy in acute cerebral infarction was performed by using Fleiss model and Dersimonian and Laird model respectively.Our results showed that the pooled total improvement rate of intravenous urokinase group was 4.85 times that of control group (95%CI: 2.73 ～ 8.62 ).There was a significant difference between the pooled total improvement rate of intravenous urokinase thrombolytic therapy and control group( χ 2= 54.30 ; P < 0.001 ).We are led to conclude that the thrombolytic therapy of intravenous urokinase was very effective for acute cerebral infarction.