长春新碱、强的松及雷公藤多甙治疗脾功能亢进的临床探讨

Clinical research about patients with hypersplenism treated with Vincristine prednison and multiglocosidorum tripterygii

目的 :研究药物治疗脾功能亢进 (脾亢 )的疗效。方法 :采用长春新碱 ( VCR)、强的松 ( Pred)及雷公藤多甙 ( Tripterygium m ultiglycosidorum) ( VPT)方案治疗脾亢患者。结果 :10例脾亢患者用药第 1周均见脾脏缩小 ,第 4周明显缩小 ,第 6周 6例脾脏肋下未触及 ,另 4例 B型超声检查脾长径平均缩小 3.1cm。 10例肝门静脉( PV)直径除 1例由 1.6 cm减至 1.4cm外 ,余均在 1.3 cm以下。随着脾脏缩小 ,WBC、BPC、HB均相继恢复正常。随访 1年以上 ,远期有效率为 80 %。结论 :脾亢系免疫因素引起 ,VPT方案为免疫抑制剂 。

Objective:To investigated the effect of treating hypersplenism with drugs.Methods:Treat hypersplenism with VPT LVCR,Pred,Tripteryginm multiglycosidonum.Results:In ten patients the spleens reduced after theat first week after treatment,significantly reduced at the four week.The spleens conldn′t touched under ribs in 6 cases at the six weeks after treatment.The length of spleens reduced average 3.1 cm in the other four cases lmder ultrasonic wave.In ten cases,besides one patient′s diameter of PV neduced from 1.6 cm to 1.4 cm, others were less than 1.3 cm WBC BPC and Hb were rised to nomal with reduction of spleens.The effective rate was 80% with following up over one year.Conclsion:VPT treatment were immure inhibitors,They conld used in treating hypersplenism which was related to immunity.