2型糖尿病患者空腹血清ghrelin与体成分的相关性研究

Correlation between fasting serum ghrelin level and body composition in patients with type 2 diabetes mellitus

目的探讨2型糖尿病(T2DM)患者空腹血清ghrelin与体成分、腹部脂肪分布、瘦素等的相关关系。方法检测40例初诊2型糖尿病患者的腰围、血压、血脂、血糖、空腹瘦素、胰岛素、ghrelin和HOMA-IR,生物电阻抗仪测体成分,螺旋CT测腹部脂肪分布,与35例健康人(对照组)进行比较,并做ghrelin与各指标间的相关性分析。结果 2型糖尿病患者的空腹血清ghrelin较正常人低(P<0.01);其与空腹血清瘦素水平呈正相关(r=0.431,P<0.05),与腹部内脏脂肪体积呈负相关(r=-0.782,P<0.01),与全身脂肪含量无显著相关性;女性血清ghre-lin水平较男性高(P=0.011)。结论 2型糖尿病患者的空腹血清ghrelin与腹部内脏脂肪体积呈负相关,提示ghrelin水平的降低可能与腹型肥胖、2型糖尿病有关。

Objective To investigate the relationship between fasting serum ghrelin level,body composition,abdominal fat distribution and leptin in patients with type 2 diabetes mellitus（T2DM）.Methods 40 newly diagnosed T2DM patients and 35 controls were measured for waist circumference,blood pressure,blood glucose,serum lipids,leptin,insulin,ghrelin and HOMA-IR.The body composition and the abdominal fat distribution were measured by bioelectrical impedance analysis and spiral CT.Correlation was analyzed between ghrelin levels and other indexes.Results Fasting serum ghrelin levels of the T2DM patients were lower than those of the controls（P0.01）.In the T2DM patients the serum ghrelin levels were positively associated with the leptin levels（r=0.431,P0.05）,and negatively associated with abdominal visceral fat volume（r=-0.782,P0.01）.But there was no relationship between total fat mass and the ghrelin level.Serum ghrelins of female patients were higher than those of male patients（P=0.011）.Conclusion In TDM patients fasting serum ghrelin level was negatively correlated with abdominal visceral fat volume,which suggests that the reduction of the ghrelin level may be associated with abdominal obesity and T2DM.