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补体调控异常相关的溶血尿毒综合征 被引量：2

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摘要 溶血尿毒综合征（hemolytic uremic syndrome，HUS）是儿童急性肾衰竭最常见的原因，属于全身性血栓性微血管病，临床以微血管病性溶血性贫血、血小板减少和急性肾衰竭为特征。以往根据有无腹泻症状将HUS分为腹泻后HUS（D HUS，即典型HUS）和非腹泻后HUS（D—HUS，即非典型HUS）。其中非典型HUS占儿童HUS的5％～10％，
作者 管娜
机构地区 北京大学第一医院儿科
出处 《中华儿科杂志》 CAS CSCD 北大核心 2012年第4期286-289,共4页 Chinese Journal of Pediatrics
关键词 溶血尿毒综合征 调控异常 微血管病性溶血性贫血 血栓性微血管病 急性肾衰竭 补体 腹泻症状 血小板减少
分类号 R726.9 [医药卫生—儿科]
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参考文献39

  • 1Besbas N,Karpman D,Landau D. A classification of hemolytic uremic syndrome and thrombotic thrombocytopenic purpura and related disorders[J].Kidney International,2006.423-431.
  • 2Waters AM,Licht C. aHUS caused by complement dysregulation:new therapies on the horizon[J].Pediatric Nephrology,2011.41-57.
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同被引文献47

  • 1Waters AM,Licht C. Ahus caused by complement dysregulation:new therapies on the horizon [J]. Pediatr Nephrol, 2011,26:41-57.
  • 2Moore I, Strain L, Pappworth I,et al. Association of factor Hautoantibodies with deletions of CFHR1,CFHR3 , CFHR4, andwith mutations in CFH,CFI,CD46,and C3 in patients withatypical hemolytic uremic syndrome [J] . Blood, 2010,115:379-387.
  • 3Ariceta G, Besbas N, Johnson S, et al. European Paediatric StudyGroup for HUS. Guideline for the investigation and initial therapyof diarrhea-negative hemolyticuremic syndrome [J] . PediatrNephrol, 2009, 24: 687-696.
  • 4Filler G,Radhakrishnan S,Strain L,et al. Challenges in themanagement of infantile factor H associated hemolytic uremicsyndrome[J]. Pediatr Nephrol, 2004, 19: 908-911.
  • 5Dragon-Durey MA,Loirat C,Cloarec S,et al. Anti-Factor Hautoantibodies associated with atypical hemolytic uremic syndrome[J]. J Am Soc Nephrol, 2005,16: 555-563.
  • 6Dragon-Durey MA, Sethi SK, Bagga A, et al. Clinical features ofanti-factor H autoantibody-associated hemolytic uremic syndrome[J]. J Am Soc Nephrol, 2010, 21:2180-2187.
  • 7Boyer 0,Balzamo E, Charbit M, et al. Pulse cyclophosphamidetherapy and clinical remission in atypical hemolytic uremicsyndrome with anti-complement factor H autoantibodies [J]. Am JKidney Dis, 2010, 55: 923-927.
  • 8Sellier-Leclerc AL, Fremeaux-Bacchi V, Dragon-Durey MA, etal. Differential impact of complement mutations on clinicalcharacteristics in atypical hemolytic uremic syndrome[J]. J AmSoc Nephrol, 2007,18: 2392-2400.
  • 9Huang Y,Liu Z,Huang H,et al. Effects of mycophenolic acid onendothelial cells [J] . Int Immunopharmacol, 2005,5: 1029-1039.
  • 10Loirat C, Fr6meaux-Bacchi V. Atypical hemolytic uremic syndrome [J]. Orphanet J Rare Dis, 2011, 6:60.

引证文献2

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中华儿科杂志
2012年 第4期

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