左旋精氨酸对体外循环缺血再灌注损伤心肌的保护作用

Protective Effect of L-arginine on Postischemia Reperfusion Myocardium During Extracorporeal Circulation

Objective\ To explore the protective effects of L arginine on myocardial ischemia reperfusion injury in patients undergoing extracorporeal circulation(ECC).\ Methods\ Sixteen patients undergoing open heart surgery were randomly divided into two groups:control group( n=8) and treated group( n=8) . Before aortic clamping and 2 hours, 4 hours, 8 hours after aortic off clamping, blood samples were taken to measure the levels of nitric oxide(NO), the activities of lactic dehydrogenase (LDH) and crentine phosphokinase (CPK).\ Results\ In control group NO level decreased remarkably ( P <0.05 or P<0.01) and LDH or CPK activity increased significantly ( P<0.01) at different time points after aortic off clamping as compared with that before aortic clamping; In treated group NO level did not decrease and activities of LDH and CPK increased slightly, and there were significant differences about parameters as above between control group and treated group ( P<0.05 and P<0 01) .\ Conclusion\ L arginine has notable protective effects on postischemia reperfusion myocardium during extracorporeal circulation which is due to its raising NO level.