银屑病与真菌感染的关系及应用联苯苄唑治疗效果观察

Relationship between Fungi and Psoriasis and the Effect of the Treatment with Bifonazole

目的 探讨银屑病发病与真菌感染的关系及观察联苯苄唑治疗效果。方法 对银屑病病人进行了真菌学研究和外用 1%联苯苄唑霜与 0 .1%氯氟舒松霜对照治疗。结果 银屑病患者糠秕孢子菌和白念珠菌带菌率高于正常对照(P <0 .0 1) ,且治疗前高于治疗后 (P <0 .0 1或P <0 .0 5 ) ,1%联苯苄唑霜与 0 .1%氯氟舒松霜疗效无显著性差异 (P >0 .0 5 )。结论 糠秕孢子菌和白念珠菌在银屑病的发病和加重过程中起着同一作用 ,联苯苄唑霜是治疗银屑病的较好的药物之一。

Objective To investigate the relationship between psoriasis and fungi and the treatment of psoriasis with bifonazole.Method A comparative study of psoriatic patients and normal controls in medical mycology and the curative effect of 1% bifonazole cream and 0.1% halcinonide cream was carried out. Results The carrying rates of Pityrosporum yeasts and Candida albicans in psoriatic patients were higher than that in normal controls (P<0.01), and higher before treatment than that after treatment (P<0.01 or P<0.05) in psoriatic patients. 1% Bifonazole cream was more effective than 0.1% halcinonide cream (P<0.05). Conclusion Pityrosporum yeast and Candida albicans may play important roles in the prevatence of psoriasis. Bifonazole could be effective medications to treat psoriasis.