肝肉瘤样癌1例并文献复习

One case of sarcomatoid hepatocellular carcinoma and literature review

目的:探讨肝肉瘤样癌患者的临床及病理学特征、诊断、鉴别诊断、治疗和预后。方法:结合我院收治的肝肉瘤样癌1例临床资料,分析国内外文献报道的该病临床特点、影像学表现、病理学特点,治疗和预后。结果:大部分该病患者均有腹痛和发热的临床表现,病理学上肿瘤都包含明确的恶性上皮性成分和梭形细胞肉瘤样成分且上皮和间叶性两种标记物表达阳性,愈后差。结论:肝肉瘤样癌是一种罕见的恶性肿瘤,恶性程度高,浸润性强,病因不明,目前无有效治疗,预后很差。

Objective： To investigate the histological features,clinical manifestations,diagnosis and prognosis of sarcomatiod hepatocellular carcinoma.Methods： One case of sarcomatoid hepatocellular carcinoma was treated at our hospital.The clinical features,imaging findings,pathological features,treatment and prognosis were analyzed of the disease reported in the literature.Results： Most of the patients had fever and abdominal pain with the disease.Tumor contains explicit elements of malignant epithelial and spindle cell sarcoma sample component and two kinds of epithelial and mesenchymal marker expression was positive.Conclusion： Sarcomatiod hepatocellular carcinoma is a rare tumor with highly malignant,invasive strong,unknown etiology,no effective treatment and the prognosis is poor.