p53蛋白表达与上皮性卵巢癌恶性程度及预后的关系研究

The significance of p53 in epithelial ovarian carcinoma prognosis and clinicopathology

目的:研究p53蛋白表达与上皮性卵巢癌恶性程度及预后的关系。方法:采用免疫组化SP法测定26例上皮性卵巢癌中p53蛋白表达。结果:p53蛋白在黏液性、浆液性、内膜样卵巢癌中的表达率(88.9%、75%、100%)无明显差异(P>0.05);三种卵巢癌的复发率分别为33.3%、12.5%、0,以黏液性癌最高,三者之间有显著差异(P<0.05);p53蛋白在淋巴结转移卵巢癌患者中均为高表达(100%),与无淋巴结转移者(68.75%)相比差异明显(P<0.05);另外,淋巴结转移卵巢癌患者的复发率(40%)较无淋巴结转移患者(6.25%)明显增高(P<0.05)。p53蛋白在I-II期和III-IV期卵巢癌的高表达(50%、100%)具有显著差异(P<0.01),不同期别卵巢癌复发的几率也存在显著差异,其中I-II期复发率为0,III-IV期复发率为31.25%。结论:p53蛋白的高表达与上皮性卵巢癌的恶性程度及预后有着密切的关系。

Objective： To investigate the significance of p53 expression of epithelial ovarian carcinoma.Methods：To use immunohistoehemical method to detect the p53 expression in 26 patients with epithelial ovarian carcinoma.Results： The expression of p53 protein in epithelial ovarian cancer（pituita,serosity,intima） had no significant difference（88.9%,75%,100%）（P 0.05） in these three groups,while the recurrence rates among three cancer subtypes were significantly different（33.3%,12.5%,0）.p53 protein expression in patients with lymph node metastasis was very strong（100%）,and there was significant difference between the former and that without lymph node metastasis（68.75%）（P 0.05）.The recurrence rate of the patients with lymph node metastasis（40%） was higher than that without lymph node metastasis（6.25%）,（P 0.05）.The high expression of p53 protein in ovarian cancer between I-II（50%） stage and III-IV stage（100%） was significantly different（P 0.05）,and the recurrence rate was different（P 0.05）.Conclusion： The expression of p53 protein has relationship with malignancy degree and prognosis of ovarian cancer.