蟾蜍制剂诱导肿瘤细胞凋亡的研究进展

Research progresstoad preparations induced tumor cell apoptosis

蟾蜍制剂是我国传统中药材,具有镇痛、消炎、麻醉等作用。近年来研究表明其具有多种抗肿瘤作用,包括诱导细胞凋亡,抑制增殖,促进细胞分化,抑制肿瘤血管形成等作用。而近几年来,以研究蟾蜍制剂诱导肿瘤细胞凋亡作用机制最多,本文主要就近几年来蟾蜍制剂:华蟾素、蟾毒灵及华蟾毒精诱导细胞凋亡作用机制的研究进展做一综述。

Venenum bufonis,as one of the traditional Chinese material medica,has functions in analgesia,eliminating inflammation,anesthesia et al.Recent studies indicated that venenum bufonis has the distinguished anticanceractivity.It could induce apoptosis,inhibit the cell proliferation,promote the cell differentiation,reverse the drug re sistance,restrain neovacularization.This review mainly summarizes the apoptosis-inducing effects of toad preparations（Cinobufacini,Bufalin and Cinobufagin） in recent years.