摘要
目的探讨24h双探针pH检测在咽喉反流疾病(laryngopharyngeal reflux disease,LPR)诊治中的临床意义。方法依据pH检测24h内食管上端反流事件次数超过6.9次为基线将难治性咽喉炎患者分为LPR组和对照组各17例,并给予咽喉炎常规治疗+抑酸治疗。分析pH检测与反流症状指数(The reflux symptom index,RSI)量表和反流检查(The reflux finding score,RFS)评分的一致性,比较两组治疗前后RSI、RFS的变化情况。结果LPR组坐立位反流次数中位数(10.0)明显高于平卧位(3.0),两者差异有统计学意义(Z=-3.62,P〈0.01),而对照组两者差异无统计学意义(Z=-0.60,P〉0.05)。pH检测判断LPR阳性结果与RSI量表、RSI量表+RFS评分的判断结果差异无统计学意义(P〉0.05),Kappa检验有统计学意义(κ值分别为0.47和0.53,P值均〈0.01)。治疗后LPR组与对照组的RSI、RFS均有不同程度下降,但LPR组的下降幅度明显高于对照组,差异均有统计学意义(t值分别为3.74、3.01,P值均〈0.01)。结论pH检测是LPR临床抗酸治疗的重要依据。
Objective To determine the clinical value of 24 h double-probe pH-metry for the diagnosis and treatment of laryngopharyngeal reflux (LPR). Methods According to the pH-metry results (whether the reflux events record in the upper esophagus is more than 6. 9 ), patients of refractory pharyngolaryngitis were divided into LPR and control groups (each of 17 cases ). All patients treated with anti-acid therapy and conventional pharyngo-laryngitis therapy. Correlation between pH-metry and the reflux symptom index (RSI) , the reflux symptom index (RFI) were analyzed. Changes of the RSI and RFI in different group were calculated in post-treatment. Results In the LPR group , the median reflux events of the upright time were higher than the supine time ( Z = - 3.62, P 〈 0. 01 ), but the difference was not discovered in the control group( Z = - 0. 60, P 〉 0.05 ). There were no statistical difference between RSI,RSI and RFS with pH-metry, and with moderate concordance ( ~ were 0.47,0. 53, P 〈 0. 01, respectively). Compared to pre-treatment, the RSI and RFI were decreased both in LPR group and contorl group, Amplitude decreased in LPR group significantly higher than the contorl groups, with statistical difference (t were 3.74,3.01, P 〈0.01, respectively). Conclusion The 24 h double-probe pH-metry is significant for the anti-acid therapy of LPR.
出处
《中华耳鼻咽喉头颈外科杂志》
CAS
CSCD
北大核心
2012年第4期320-323,共4页
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
基金
浙江省医药卫生科技计划A类项目(2009A187)
关键词
氢离子浓度
胃食管反流
诊断
Hydrogen-ion concentration
Gastroesophageal reflux
Diagnosis