白虎加人参汤加味治疗肿瘤性发热疗效观察

Curative Effect of Modified Baihu Jia Rensheng Decoction in the Treatment of Tumor Fever

目的探讨白虎加人参汤加味在肿瘤性发热患者中的治疗效果。方法从2005年6月—2011年5月我院收治的肿瘤性发热患者中随机选择近期未做放化疗,知情并同意参加本次研究的患者58例,随机分为观察组和对照组,分别实施白虎加人参汤加味加减治疗和吲哚美辛(消炎痛)治疗,观察两组治疗效果、平均退热时间及毒副作用。结果观察组29例患者中13例治愈、7例显效、4例有效、5例无效,治愈率为44.83%,总有效率为82.76%;对照组29例患者中6例治愈、8例显效、5例有效、10例无效,治愈率为20.69%,总有效率为65.52%。两组疗效间差异有统计学意义(P<0.05)。观察组患者平均体温由38.5℃降至36.5℃,平均退热时间为(1.5±0.2)d,对照组患者平均体温则由38.4℃降至37.1℃,平均退热时间为(3.5±0.3)d,两组平均退热时间比较差异有统计学意义(P<0.05)。疗程结束后对照组2例患者白细胞计数下降明显,观察组无一例白细胞计数下降。结论白虎加人参汤加味治疗肿瘤性发热临床治疗效果明显,退热时间快,效果平稳、持久,且无毒副作用,值得推广。

Objective To study the curative effect of modified Baihu jia Renshen decoction in the treatment of patients with tumor fever. Methods 58 tumor fever patients who didn＇t receive chemoradiotherapy and who admitted to our hospital from June 2005 to May 2011 were randomly selected, and they were equally divided into observation group and control group, with the two groups receiving modified Baihu jia Renshen decoction and Indocin respectively. The curative effect, average time of deferves- cence and side effects of the two groups were observed. Results Of the 29 patients in observation group, 13 cases were cured, 7 cases were remarkably improved, 4 cases were improved and 5 cases were ineffective, the cure rate was 44. 83% and the overall effective rate was 82. 76% ; of the 29 patients in control group, 6 cases were cured, 8 cases were remarkably improved, 5 cases were improved and 10 cases were ineffective, the cure rate was 20. 69% and the overall effective rate was 65.52%. The curative effect of the observation group was significantly better than that of the control group （ P 〈 0. 05） . The average body temperature dropped from 38. 5 ℃ to 36. 5 ℃ in observation group with average defervescence time of （1.5±0. 2） d; while the average body temperature dropped from 38.4 ℃ to 37.1 ℃ in control group with average defervescenee time of （ 3.5±0. 3） d. The difference of average defervescenee time between the two groups was statistically significant （ P 〈 0. 05 ） . After treatment, while blood cell of two patients in control group reduced significantly, but there was no such reduction in observation group. Conclusion The modified Baihu jia Renshen decoction is effective in treating tumor fever with short defervescence time, stable and lasting effect. It has no side effect and should be recommended.